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Valery Fokin

Professor of Chemistry

Office: MCB 359
Phone: 213-740-5964

Research Focus


Selected publications


  1. Schwartz, E.; Breteinkamp, K.; Fokin, V. V. Synthesis and Post-polymerization Functionalization of Poly(5-iodo-1,2,3-triazole)s, Macromolecules 201144, 4735-41.
  2. Chuprakov, S.; Malik, J.; Zibinsky, M.; Fokin, V. V. Catalytic Asymmetric C–H Insertions of   Rhodium(II)  Azavinyl Carbenes., J. Am. Chem. Soc. 2011133,10352-55.
  3. Zibinsky, M., Fokin, V.V. Reactivity of N-(1,2,4-Triazolyl)-Substituted 1,2,3-Triazoles. Org. Lett. 201113, 4870-4872.
  4. Grimster, N.P., Stump, B., Fotsing, J.R., Weide, T., Talley, T.T., Yamauchi, J.G., Nemecz, A., Kim, C., Ho, K.-Y., Sharpless, K.B., Taylor, P., Fokin, V.V. Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors Via in Situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template. J. Am. Chem. Soc. 2012134, 6732-6740.
  5. Selander, N., Fokin, V.V. Rhodium(II)-Catalyzed Asymmetric Sulfur(VI) Reduction of Diazo Sulfonylamidines. J. Am. Chem. Soc. 2012134, 2477-2480.
  6. Selander, N., Worrell, B.T., Chuprakov, S., Velaparthi, S., Fokin, V.V. Arylation of Rhodium(II) Azavinyl Carbenes with Boronic Acids. J. Am. Chem. Soc. 2012134, 14670-14673.
  7. Zibinsky, M., Fokin, V.V. 1-Sulfonyl-1,2,3-Triazoles: Convenient Synthones for Heterocyclic Compounds. Angew. Chem., Int. Ed. 201352, 1507-1510.
  8. Selander, N., Worrell, B.T., Fokin, V.V. Ring Expansion and Rearrangements of Rhodium(II) Azavinyl Carbenes Angew. Chem. Int. Ed. 201251, 13054-13057.
  9. Rillahan, C.D., Schwartz, E., McBride, R., Fokin, V.V., Paulson, J.C. Click and Pick: Identification of Sialoside Analogues for Siglec-Based Cell Targeting. Angew. Chem. Int. Ed. 201251, 11014-11018.
  10. Chanda, A., Fokin, V.V., in Science of Synthesis. (Ed.: S. Kobayashi): Thieme, Stuttgart•New York, 20122011/7, pp. 697-748.
  11. Oakdale, J.S., Fokin, V.V. Preparation of 1,5-Disubstituted 1,2,3-Triazoles Via Ruthenium-Catalyzed Azide-Alkyne Cycloaddition. Org. Synth. 201390, 96-104.
  12. Kovarik, Z., Macek, N., Sit, R.K., Radic, Z., Fokin, V.V., Barry, S.K., Taylor, P. Centrally Acting Oximes in Reactivation of Tabun-Phosphoramidated AChE. Chem.-Biol. Interact. 2013203, 77-80.
  13. Radic, Z., Sit, R.K., Garcia, E., Zhang, L., Berend, S., Kovarik, Z., Amitai, G., Fokin, V.V., Barry, S.K., Taylor, P. Mechanism of Interaction of Novel Uncharged, Centrally Active Reactivators with OP-hAChE Conjugates. Chem.-Biol. Interact. 2013203, 67-71.
  14. Worrell, B.T.; Malik, J.A.; Fokin, V.V. Direct Evidence of a Dinuclear Copper Intermediate in Cu(I)-Catalyzed Azide–Alkyne Cycloadditions. Science 2013340, 457-460.
  15. 15.    Chuprakov, S., Kwok, S.W., Fokin, V.V. Transannulation of 1-Sulfonyl-1,2,3-Triazoles with Heterocumulenes. J Am Chem Soc 2013135, 4652-4655. 
  16. 16.    Sanphanya, K., Wattanapitayakul, S.K., Phowichit, S., Fokin, V.V., Vajragupta, O. Novel VEGFR-2 Kinase Inhibitors Identified by the Back-to-Front Approach. Bioorg Med Chem Lett 201323, 2962-2967.
  17. Rillahan, C. D.; Schwartz, E.; Rademacher, C.; McBride, R.; Rangarajan, J.; Fokin, V. V.; Paulson, J. C. On-Chip Synthesis and Screening of a Sialoside Library Yields a High Affinity Ligand for Siglec-7 ACS Chem. Biol. 20138, 1417.
  18. Worrell, B. T.; Ellery, S. P.; Fokin, V. V. Copper(I)-Catalyzed Cycloaddition of Bismuth(III) Acetylides with Organic Azides: Synthesis of Stable Triazole Anion Equivalents Angew. Chem., Int. Ed. 201352, 13037.
  19. Chuprakov, S.; Worrell, B. T.; Selander, N.; Sit, R. K.; Fokin, V. V. Stereoselective 1,3-Insertions of Rhodium(II) Azavinyl Carbenes J. Am. Chem. Soc. 2014136, 195.
  20. Kwok, S. W.; Zhang, L.; Grimster, N. P.; Fokin, V. V. Catalytic Asymmetric Transannulation of NH-1,2,3-Triazoles with Olefins Angew. Chem., Int. Ed. 201453, 3452.
  21. Rillahan, C. D.; Macauley, M. S.; Schwartz, E.; He, Y.; McBride, R.; Arlian, B. M.; Rangarajan, J.; Fokin, V. V.; Paulson, J. C. Disubstituted sialic acid ligands targeting siglecs CD33 and CD22 associated with myeloid leukaemias and B cell lymphomas Chem. Sci. 20145, 2398.
  22. Oakdale J.S.; Sit R.K., Fokin V.V. Ruthenium-Catalyzed Cycloadditions of 1-Haloalkynes with Nitrile Oxides and Organic Azides: Synthesis of 4-Haloisoxazoles and 5-Halotriazoles. Chem - Eur J2014; 20, 11101.
  23. Dong J., Sharpless K.B., Kwisnek L, Oakdale J.S., Fokin V.V. SuFEx-Based Synthesis of Polysulfates. Angew Chem, Int Ed2014; 53, 9466.
  24. Sitnikov, N. S.; Kokisheva, A. S.; Fukin, G. K.; Neudoerfl, J.-M.; Sutorius, H.; Prokop, A.; Fokin, V. V.; Schmalz, H.-G.; Fedorov, A. Y. Eur. J. Org. Chem. 20142014, 6481
  25. Voitovich, Y. V.; Shegravina, E. S.; Sitnikov, N. S.; Faerman, V. I.; Fokin, V. V.; Schmalz, H.-G.; Combes, S.; Allegro, D.; Barbier, P.; Beletskaya, I. P.; Svirshchevskaya, E. V.; Fedorov, A. Y. J. Med. Chem. 201558, 692.

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