New Approaches to Hydride Manipulation
We are developing new catalysts and conditions to manipulate hydrides such as various C-H and other X-H bonds. Particularly, we're interested in coordinatively directed hydride abstraction and new reactions for complex molecule synthesis that feature C-H activation. It's like a "carrot and stick" approach, in which a Lewis acid directing group directs a target substrate to a reactive metal center.
To achieve these goals, we will employ strategies of catalyst design, thus exploring novel organometallic and coordination chemistry, and target-oriented new organic reaction development.
Chemical Probes for Biology and Medicine
Simultaneously and synergistically with our organometallic work, we are devising conceptually novel chemical tools for research and clinical use. Along these lines, we are currently developing the first ultrasound-activated MRI contrast agent.