Professor James Kindt
The lipid bilayer is a structure of great interest as the foundation for biological membranes. A typical biomembrane contains a mixture of many distinct lipid species; as the composition of this mixture is closely regulated and specific to cell and organelle type, one may presume that the structures of these lipids matter to biological function. A general question then arises: to what extent are lipids of different types distributed homogeneously throughout a membrane, and to what extent are they grouped together by type or partitioned among different microenvironments within the membrane? In this talk, the challenge of addressing this question through conventional computer simulation methods, and results from a very efficient semi-grand canonical ensemble approach, will be presented.